Aim and objectives

The project aims at developing a new multi-scale (integrated molecular, cellular and network levels) data-driven in silico model of the hippocampal CA1 region under Alzheimer’s disease conditions.

The main project objectives:

  1. Extend the experimental evidence of Amyloid beta (Aβ), Amyloid eta (Aη), Amyloid precursor protein C-terminal peptide (AICD)-related changes in the properties of hippocampal CA1 pyramidal neuron synaptic plasticity, synaptic signal integration and neuronal excitability.
  2. Incorporate the dose-dependent effects of Alzheimer’s disease-related peptides into computational models of hippocampal synaptic plasticity, CA1 pyramidal neurons and CA1 network; determine and explain the molecular, synaptic, cellular, network-level mechanisms of altered hippocampal function that leads to impaired learning and progressive irreversible memory loss in Alzheimer’s disease.
  3. Identify and assess experimentally and by computational modeling potential targets for innovative treatment of Alzheimer’s disease.

Select any filter and click on Apply to or press ENTER see results