Aim and objectives
The project aims at developing a new multi-scale (integrated molecular, cellular and network levels) data-driven in silico model of the hippocampal CA1 region under Alzheimer’s disease conditions.
The main project objectives:
- Extend the experimental evidence of Amyloid beta (Aβ), Amyloid eta (Aη), Amyloid precursor protein C-terminal peptide (AICD)-related changes in the properties of hippocampal CA1 pyramidal neuron synaptic plasticity, synaptic signal integration and neuronal excitability.
- Incorporate the dose-dependent effects of Alzheimer’s disease-related peptides into computational models of hippocampal synaptic plasticity, CA1 pyramidal neurons and CA1 network; determine and explain the molecular, synaptic, cellular, network-level mechanisms of altered hippocampal function that leads to impaired learning and progressive irreversible memory loss in Alzheimer’s disease.
- Identify and assess experimentally and by computational modeling potential targets for innovative treatment of Alzheimer’s disease.
The project aims at developing a new multi-scale (integrated molecular, cellular and network levels) data-driven in silico model of the hippocampal CA1 region under Alzheimer’s disease conditions.
The main project objectives:
- Extend the experimental evidence of Amyloid beta (Aβ), Amyloid eta (Aη), Amyloid precursor protein C-terminal peptide (AICD)-related changes in the properties of hippocampal CA1 pyramidal neuron synaptic plasticity, synaptic signal integration and neuronal excitability.
- Incorporate the dose-dependent effects of Alzheimer’s disease-related peptides into computational models of hippocampal synaptic plasticity, CA1 pyramidal neurons and CA1 network; determine and explain the molecular, synaptic, cellular, network-level mechanisms of altered hippocampal function that leads to impaired learning and progressive irreversible memory loss in Alzheimer’s disease.
- Identify and assess experimentally and by computational modeling potential targets for innovative treatment of Alzheimer’s disease.