Michele Migliore, PhD

Prof Michele Migliore

Institute of Biophysics, Palermo, Italy

Over the past 30 years the Computational Neuroscience Laboratory of CNR-IBF, headed by Prof. Michele Migliore, has been involved in the development and implementation of computational models of complex systems.

The broad long-term goal is to investigate, using realistic models and state of the art simulations techniques, the basic processes underlying the nervous system functions and dysfunctions. In close interdisciplinary collaboration with leading experimental laboratories, we investigate neuronal networks and single neurons at different integration levels, always closely related to the available experimental data. The primary current research interests are the mechanisms of learning and memory, synaptic integration, and ion channels function, in the attempt to link behavioral and dysfunctional processes with signal processing at the single neuron or network level.

Key Publications:
Einevoll GT, Destexhe A, Diesmann M, Grün S, Jirsa V, de Kamps M, Migliore M, Ness TV, Plesser HE, Schürmann F. The Scientific Case for Brain Simulations. Neuron 2019;102:735-744.

Martinello K, Giacalone E, Migliore M, Brown DA, Shah MM. The subthreshold-active KV7 current regulates neurotransmission by limiting spike-induced Ca2+ influx in hippocampal mossy fiber synaptic terminals. Nature Commun Biol. 2019;26;2:145.

Solinas SMG, Edelmann E, Leßmann V, Migliore M. A kinetic model for Brain-Derived Neurotrophic Factor mediated spike timing-dependent LTP. PLoS Comput Biol. 2019;15(4): e1006975.

Migliore R, Lupascu CA, Bologna LL, Romani A, Courcol JD, Antonel S, Van Geit WAH, Thomson AM, Mercer A, Lange S, Falck J, Rössert CA, Shi Y, Hagens O, Pezzoli M, Freund TF, Kali S, Muller EB, Schürmann F, Markram H, Migliore M. The physiological variability of channel density in hippocampal CA1 pyramidal cells and interneurons explored using a unified data-driven modeling workflow. PLoS Comput Biol. 2018;14(9):1-5.

Cavarretta F, Burton SD, Igarashi KM, Shepherd GM, Hines ML, Migliore M. Parallel odor processing by mitral and middle tufted cells in the olfactory bulb. Nature Sci Rep. 2018; 16;8:7625.

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